The Arab League was formed in Cairo on 22 March 1945 with six members: Egypt, Iraq, Transjordan (renamed Jordan after independence in 1946), Lebanon, Saudi Arabia, and Syria. Yemen joined on 5 May 1945. Since its formation the Arab League has promoted the Palestinian Arab cause in the Israeli–Palestinian conflict, including by imposing the Arab League boycott of Israel. The Arab League opposed the United Nations Partition Plan for Palestine in 1947. On 15 May 1948, the then seven Arab League members coordinated an invasion of what was by then the former British Mandate, marking the start of the 1948 Arab–Israeli War.

In 1964, the Arab League created the Palestine Liberation Organization to operate within the territory of Israel. During the Six-Day War, the Arab League was instrumental in the oil embargo, which lasted until the Khartoum Resolution in September 1967. The League members also agreed to continue the state of belligerency with Israel and not to negotiate a settlement to the conflict. The signing of the Egypt–Israel peace treaty was condemned, and Egypt was suspended from the Arab League in 1979, which lasted until 1989. The Arab League on 15 November 1988 recognized the proclamation of the State of Palestine. The Palestine Liberation Organization and Israel signed the Oslo Accords in 1993 which led to the setting up of the Palestinian National Authority. The Arab League has not made any official statements either supporting the establishment of the Palestinian Authority or condemning it. In October 1994, Jordan signed the Israel–Jordan peace treaty with Israel, and it was not ostracized by the Arab League, as Egypt had been in 1979. In 2002, the Arab League endorsed a Saudi Arabian Arab Peace Initiative which called for full withdrawal by Israel "to the 1967 borders" in return for fully normalized relations.